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Home > Introduction of our tenure-track faculties > Murakami Tomoaki

Introduction of our tenure-track faculties

Murakami Tomoaki

Affiliation Institute of Agriculture
Division Division of Animal Life Science
Research field Veterinary Toxicology, Veterinary Pathology, Protein folding-diseases
Keyword(S) Amyloid, Transmission, Food animals, Experimental animals
Research experience

・April 2013 to September 2013: JSPS Research Fellow DC2
・October 2013 to October 2013: JSPS Research Fellow PD
・November 2013 to Present: Assistant Professor, TUAT

Educational background

・D.V.M. 2010 Veterinary Medical Science, Obihiro University of Agriculture and Veterinary Medicine
・Ph.D. 2013 Veterinary Medical Science, Gifu University

Selected papers and publications

・Murakami T, Inoshima Y, Watanabe K, Kobayashi Y, Matsui T, Kurazono H, Ishiguro N.,"Pathogenesis of experimental amyloid protein A amyloidosis in sore hocks-affected rabbits.", Amyloid, 18(3): 112-118, 2011.
・Murakami T, Kobayashi Y, Chiba S, Kurauchi Y, Sakamoto H, Sasaki M, Matsui T., "Humeral Chondrosarcoma in a Hokkaido brown bear (Ursus arctos yesoensis).", J Vet Med Sci, 74(9): 1195-1197, 2012
・Murakami T, Inoshima Y, Kobayashi Y, Matsui T, Inokuma H, Ishiguro N., "Atypical AA amyloid deposits in bovine AA amyloidosis.", Amyloid, 19(1): 15-20, 2012
・Murakami T, Inoshima Y, Sakamoto E, Fukushi H, Sakai H, Yanai T, Ishiguro N., "AA amyloidosis in vaccinated growing chickens.", J Comp Pathol, 149: 291-297, 2013
・Murakami T, Inoshima Y, Yanai T, Goryo M, Ishiguro N., "Experimental induction and oral transmission of avian AA amyloidosis in vaccinated white hens.", Amyloid, 20(2): 80-85, 2013
・Murakami T, Ishiguro N, Higuchi K., "Transmission of Systemic AA Amyloidosis in Animals.", Vet Pathol. In press

Research Description

Amyloidosis is a group of protein conformation diseases characterized by an extracellular deposition of insoluble protein fibrils with β-plated structure, which results in organ damage. In several species, AA amyloidosis is the most frequently encountered fatal systemic amyloidosis, and secondary to long-standing inflammatory disorders such as rheumatoid arthritis and bacterial infections. However, details of the pathogenic mechanisms in AA amyloidosis remain obscure.
Since the publication of a recent study, which revealed that bovine and avian AA amyloidosis can be transmitted between different species, the presence of amyloid in meat for consumption may be a major public health hazard. Although ingestion of amyloid fibrils would be a trigger of amyloid formation in host animals, it is thought that some essential factor are required for progress in amyloid deposits. Microbial infections and toxicity effects are suspected as amyloid-associated factors, and following immune modulations are thought to enhance the development of amyloidosis. But the mechanisms of these phenomenon are still not clear.
The purpose of my study is to clarify the associations between the response of body to exposure to the exogenous agents and amyloid formations in vivo. This study will explain the risk of food animal amyloidosis, and lead to contribution to the national safety of food.

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About TUAT's tenure-track program

For a rooky fresh out of doctoral course, this program will be a big chance to grow as a researcher and an educator. We can dedicate to our own research thanks to abundant financial support and helpful advices by senior researchers.

Future aspirations

I'll try to be a bearer of international-standard veterinary educations. And, I'd like to be a far-sighted researcher developing new areas of research. I will welcome the collaborative research.