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Home > Introduction of our tenure-track faculties > Kawano Ryuji

Introduction of our tenure-track faculties

Kawano Ryuji

Affiliation Organization for Promotion of Tenure-track System / Institute of Engineering
Division Division of Biotechnology and Life Science
Research field Single Molecule Detection, BioMEMS
Keyword(S) Lipid bilayer, Membrane proteins, Microfluidics, Nanopore
Research experience

・2005: Lecturer, VBL, Yokohama National Univsersity
・2006: JSPS Postdoctroal Fellow, University of Utah
・2008: Postdoctral Fellow, University of Utah
・2009: Researcher, Kanagawa Academy of Science and Technology
・2014.1-present: Associate Professor, Tokyo University of Agriculture and Technology

Educational background

・2000: B. Eng., Tokyo Metropolitan University
・2005: Ph. D., Yokohama National University


・2003: The 83th Annual Meeting of The Chemical Society of Japan, Student Presentation Award
・2006: The 88th Annual Meeting of The Chemical Society of Japan, Presentation Award
・2013: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers2013 and EurosensorsXXVII, Outstanding Oral Presentation Award Nomination

Selected papers and publications

・R. Kawano, Y. Tsuji, K. Sato, T. Osaki, K. Kamiya, M. Hirano, T. Ide, N. Miki, S. Takeuchi, "Automated Parallel Recordings of Topologically Identified Single Ion Channels", Scientific Reports 2013, 3: 1995 | DOI: 10.1038/srep01995.
・D. Kiriya, R. Kawano, H. Onoe, S. Takeuchi, "Microfluidic Control of the Internal Morphology in Nanofiber-based Macroscopic Cables", Angewandte Chemie Int. Ed., 2012, 51, 7942-7947.
・R. Kawano, T. Osaki, H. Sasaki, M. Takinoue, S. Yoshizawa, S. Takeuchi, "Rapid Detection of a Cocaine-Binding Aptamer Using Biological Nanopores on a Chip", J. Am. Chem. Soc., 2011, 133, 8474-8477.
・R. Kawano, T. Osaki, H. Sasaki, S. Takeuchi, "A Polymer-based Nanopore-integrated Microfluidic Device for Generating Stable Bilayer Lipid Membranes", Small 2010, 6, 2100-2104.
・D. K. Lathrop, E. N. Ervin, G. A. Barrall, M. G. Keehan, R. Kawano, M. A. Krupka, H. S. White, and A. H. Hibbs, "Monitoring the Escape of DNA from a Nanopore Using an Alternating Current Signal", J. Am. Chem. Soc. 2010, 132, 1878-1885.
・R. Kawano, A. Schibel, C. Cauley, H. S. White, "Controlling the Translocation of Single-Stranded DNA through α-Hemolysin Ion Channels Using Viscosity", Langmuir, 2009, 25 (2), 1233–1237.

Research Description

The goal of my research is to establish a system that uses biological nanopores for single-molecule detection. Channel membrane proteins have nanochannels around 1 nm in size. These biological nanopores are capable of detecting and electrically recognize even single molecules with a high signal-to-noise ratio. However, the channel size is limited by the inherent protein structure. I plan to develop artificial nanochannels such as synthetic nanopores or polypeptides combined with biomaterials (proteins and lipid bilayers) on the basis of MEMS technology for novel nanopore sensing.

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About TUAT's tenure-track program

The tenure track program in TAT provides the provision of space and start-up funds for independent research and work for tenure track faculty. This program is promising that young researchers dedicate themselves completely to their research and education.

Future aspirations

I combine themes at the forefront of nanoscience, biomolecular engineering, and electrochemistry, for the development of innovative analytical tools and their application in both the physical and life sciences. Examples include the development of sensitive, nanometer scale chemical and biological sensors that will probe materials and biological systems with unprecedented temporal and spatial resolution. Member in my lab will gain a highly interdisciplinary background electrochemistry, biochemistry, nanotechnology and biomolecular engineering pushing the frontiers of basic science while also narrowing the gap between laboratory-bound research and real-world applicability.