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Home > Introduction of our tenure-track faculties > Yanagisawa Miho

Introduction of our tenure-track faculties

Yanagisawa Miho

Affiliation Organization for Promotion of Tenure-track System / Institute of Engineering
Division Division of Advanced Applied Physics
Research field Soft Matter Physics, Biophysics
Keyword(S) Artificial cells, Membranes, Polymers, Gels, Phase transition
Url http://web.tuat.ac.jp/~m_yanagi/enindex.html
Research experience

・Apr.2007-Mar.2009: JSPS research fellow (DC1)
・Apr.2009-Apr.2011: JSPS research fellow (PD)
・May 2011-Apr.2014: Assisant Professor, Kyushu University
・May 2014-Present: Associate Professor, Tokyo University of Agriculture and Technology

Educational background

・Mar. 2005: B.S. in Phyics, School of Science, Ochanomizu University
・Mar. 2007: M.S. in Physics, Graduate school of Humanities and Sciences, Ochanomizu University
・Mar. 2009: Ph.D. in Science, Graduate school of Humanities and Sciences, Ochanomizu University

Awards

・Jun. 2012: The 5th Shiseido Female Researcher Science Grant
・Mar. 2012: Young Scientist Award of the Physical Society of Japan
・Sep. 2011: Excellent Presentation Award, The 3rd Asian Symposium on Advanced Materials

Selected papers and publications

・M. Yanagisawa, M. Imai, T. Masui, S. Komura and T. Ohta, “Growth dynamics of domains in ternary fluid vesicles”, Biophys. J., 92:115-125 (2007).
・M. Yanagisawa, M. Imai, and T. Taniguchi, “Shape deformation of ternary vesicles coupled with phase separation”, Phys. Rev. Lett., 100:148102 (2008)
・M. Yanagisawa, M. Imai, and T. Taniguchi, “Periodic modulation of tubular vesicles induced by phase separation”, Phys. Rev. E, 82:051928, (2010)
・M. Yanagisawa et al., “Oriented reconstitution of a membrane protein in a giant unilamellar vesicle: Experimental verification with the potassium channel KcsA”, J. Am. Chem. Soc., 133:11774-11779, (2011)
・M. Yanagisawa, N. Shimokawa, M. Ichikawa and K. Yoshikawa, “Micro-segregation induced by bulky-head lipids: Formation of characteristic patterns in a giant vesicle”, Soft matter, 8:488-495, (2012)
・M. Yanagisawa, T. Yoshida, M. Furuta, S. Nakata, and M. Tokita, “Adhesive force between paired microdroplets coated with lipid monolayers”, Soft Matter, 9:5891-5897, (2013)
・M. Yanagisawa, T. Sakaue, and K. Yoshikawa, “Characteristic behavior of crowding macromolecules confined in cell-sized droplets”., Int. Rev. Cell Mol. Biol., 307: 175-204, (2014)
・K. Fujiwara and M. Yanagisawa, “Generation of giant unilamellar liposomes containing biomacromolecules at physiological intracellular concentrations using hypertonic conditions”, ACS Synth. Biol., (DOI: 10.1021/sb4001917).

Research Description

Soft matter physics express living cells as complex protein solution covered by a soft membrane. We have constructed model cell systems to explain biological phenomenon by phase transitions and critical phenomena of polymers confined in microspheres. As a core topic, we have developed research using lipid bilayer vesicles as a cell model. Multi-component vesicles show a great variety of shape deformation by accompanied with phase separation. The physical descriptions give guide to explain the mechanism that regulates cellular shapes. In addition, we are preparing more realistic cell models by installing highly-condensed protein solution as intracellular structures and exchanges of molecules across the membrane to maintain non-equilibrium state. Our research will answer the question how the livings regulate their multi-cellular shapes and structures. Through the mimicking cell research, we have successfully generated microgels with a great variety of shapes. In microdroplets, interplay among phase separation, wetting and gelation determines the microgel shape. These physical observations and the mathematical descriptions will contribute to the development of non-equilibrium statistical mechanics and non-linear science, and also numerous applications: micro-materials for drug-delivery systems, foods, cosmetics, etc.

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About TUAT's tenure-track program

The TUAT tenure-track program prepares tenure posts for all the tenure-track members. According to our own achievements, we can hold a tenured position. In addition, the TUAT provides us sufficient research fund and laboratory space. Therefore, this program nurtures us to become core members of the university and in each research area.

Future aspirations

Remarkable developments in soft matter physics, artificial cell researches, and life sciences promote cross-cutting researches from physics to biology and chemistry. It begins to dawn a new era: Physics enable to explain biological phenomenon and to organize the chemical functions by using their common words. We will reveal the physics laws that regulate cellular shapes and structures.