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Home > Introduction of our tenure-track faculties > Yoshino Daisuke

Introduction of our tenure-track faculties

Yoshino Daisuke

Affiliation Institute of Engineering
Division Division of Advanced Applied Physics
Research field Mechanobiology, Design Engineering
Keyword(S) Corculatory homeostasis, Cardiovascular disease, Design of medical devices, Cell biomechanics
Url https://sites.google.com/go.tuat.ac.jp/dyoshino-research-group/home
Research experience

・Apr. 2011–June. 2011: Staff member, Fujifilm Corporation
・July 2011-Mar. 2012: Postdoctoral Fellow, Graduate School of Biomedical Engineering, Tohoku University
・Apr. 2012–Jan. 2017: Assistant Professor, Institute of Fluid Science, Tohoku University
・Oct. 2014–Oct. 2015: Visiting Researcher, Mechanobiology Institute, National University of Singapore
・Feb. 2017–Oct. 2019: Assistant Professor, Frontier Research Institute for Interdisciplinary Sciences, Tohoku University
・Nov. 2019–present: Associate Professor, Insititute of Engineering, Tokyo University of Agriculture and Technology

Educational background

・Mar. 2006: Bachelor of Engineering, Tohoku University
・Mar. 2008: Master of Engineering, Tohoku University
・Mar. 2011: Ph.D. in Engineering, Tohoku University

Awards

・2006: Miura Award, The Japan Society of Mechanical Engineers
・2011: The 2010 Duncan Dowson Prize, The Institution of Mechanical Engineers, UK

Selected papers and publications

・D. Yoshino and M. Sato, "Early-stage dynamics in vascular endothelial cells exposed to hydrostatic pressure", Journal of Biomechanical Engineering, 141, 091006 (2019).
・D. Yoshino, N. Sakamoto, and M. Sato, "Fluid shear stress combined with shear stress spatial gradients regulates vascular endothelial morphology", Integrative Biology, 9, 584 (2017).
・Y. Sato, T. Sato, and D. Yoshino, "Characteristics of plasma generated in culture medium by positive pulse voltage and effects of organic compounds on plasma characteristics", Plasma Sources Science and Technology, 25, 065023 (2016).
・D. Yoshino, K. Sato, and M. Sato, "Endothelial cell response under hydrostatic pressure condition mimicking pressure therapy", Cellular and Molecular Bioengineering, 8, 296 (2015).
・D. Yoshino and K. Inoue, "Design method of self-expanding stents suitable for the patient’s condition", Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 224, 1019 (2010).

Research Description

Atherosclerosis has become a serious problem in the developed countries that are aging. Therefore, countermeasures to the atherosclerosis have become important. Although there are various medical treatments for the atherosclerosis, a stent placement has received much attention as a minimally invasive procedure for vascular stenotic lesion based on the coronary atherosclerosis, the arteriosclerosis obliterans, etc. A stent is a cylindrical tube-shaped medical device that can expand the stenotic lesion in a blood vessel continuously. However, the long-term placement of stents can lead to the severe problems of in-stent restenosis and stent thrombosis in blood vessels. To prevent these problems, stents coated with immunosuppresant or biomolecule now comes into general use. However, the larger force acting on the vascular wall induces vascular inflammatory reaction, and it increases the risk of long-term in-stent restenosis or stent thrombosis because of mismatch in the mechanical properties between stent and blood vessel. The hitherto existing development of a stent is trial and error, and it cannot resolve the problems of long-term in-stent restenosis or stent thrombosis.
The aim of this research is to develop the next-generation stent with high functionality through establishment of a novel design theory integrated with mechanobiology and design engineering. This research provides a cultured blood vessel model with the hemodynamic environment. This blood vessel model is useful for study about vascular pathology or drug discovery. This research also elucidates the mechanisms of in-stent restenosis and neointimal formation based on vascular mechanobiology. The results of this research can lead to an innovation in technology for cardiovascular treatment.

About TUAT's tenure-track program

The tenure track system at Tokyo University of Agriculture and Technology is well developed because a young principal investigator can receive an independent reserch environment and startup grants to promote growth as a university-based researcher and educator. In addition, the faculty members well understand the tenure track system, and they support the young investigator in various ways.

Future aspirations

In my research that focuses on basic to apploication in medical device development, I challenge to find out "something" interesting that we have never seen.