Nagaoka Kentaro:Tenured Faculties|TUAT's tenure-track program

Research Support Office Research Advancement Division. Tokyo University of Agriculture and Technology

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Nagaoka Kentaro

Affiliation	Institute of Agriculture
Division	Division of Animal Life Science
Research field	Veterinary Physiology
Keyword(S)	Endocrinology, Reproduction, Cell Biology, Stress, Mastitis
Url	http://web.tuat.ac.jp/~nvetphys/english.html

Research experience	･2000.4 - 2003.3 : JSPS Research Fellow DC1 ･2003.4 - 2004.5 : KYOWA HAKKO KOGYO CO.,LTD ･2004.6 - 2011.2 : Assistant Professor, Graduate School of Agricultural and Life Sciences, The University of Tokyo ･2009.4 - 2011.2 : Visiting Scientist, Program in Molecular Medicine, University of Massachusetts Medical School ･2009.4 - 2011.2 : JSPS Postdoctoral Fellow for Research Abroad ･2011.3 - 2016.2 : Assistant Professor, Tokyo University of Agriculture and Technology ･2016.3 - 2018.12 : Associate Professor (Tenured), Tokyo University of Agriculture and Technology ･2018.12 - Present : Professor (Career Challenge), Tokyo University of Agriculture and Technology
Educational background	･D.V.M. 1999 Veterinary Medical Science, TUAT ･Ph.D. 2003 Veterinary Medical Science, The University of Tokyo
Awards	* The latest information is shown at the member's website. (At Jul. 2019) ･50th anniversary prize MORINAGA HOSHI-KAI (2007)
Selected papers and publications	* The latest information is shown at the member's website. (At Mar. 2014) ･Nagaoka K, Udagawa T, Richter JD. CPEB-mediated ZO-1mRNA localization is required for epithelial tight-junction assembly and cell polarity. Nature Communications 3, 675, doi:10.1038/ncomms1678, 2012 ･Nagaoka K, Aoki F, Hayashi M, Muroi Y, Sakurai T, Itoh K, Ikawa M, Okabe M, Imakawa K, Sakai S. L-amino acid oxidase plays a crucial role in host defense in the mammary glands. FASEB Journal. 23, 2514-2520, 2009 ･Tanaka T, Imakawa K, Sakai S, Nagaoka K. MiR-101a controls cell proliferation by regulating cyclooxygenase-2 during mammary gland development. Differentiation. 77, 181-187, 2009 ･Sakai S, Nonobe E, Satow T, Imakawa K, Nagaoka K. Production of hydrogen peroxide by a small molecular mass compound in milk from Holstein cows with high and low milk somatic cell count. Journal of Dairy Research. 75, 335-339, 2008 ･Sakai S, Satow T, Imakawa K, Nagaoka K. Generation of hydrogen peroxide by a low molecular weight compound in whey of Holstein dairy cows. Journal of Dairy Research. 75, 257-261, 2008 ･Nagaoka K, Tanaka T, Imakawa K, Sakai S. Involvement of RNA binding proteins AUF1 in mammary gland differentiation. Experimental Cell Research. 313, 2937-2945, 2007 ･Nagaoka K, Suzuki T, Kawano T, Imakawa K, Sakai S. Stability of casein mRNA in ensured by structural interactions between the 3’-untranslated region and poly(A) tail via the HuR and poly(A)-binding protein complex. Biochimica et Biophysica Acta 1759, 132-140, 2006

Research Description

The remarkable economic development and population growth in recent years might threaten the food shortage on a global scale. I have researched on reproductive physiology and aim to contribute to the development of efficient food production. Notably I am tackling a big issue in animal science, mastitis, so-called occupational disease of dairy cattle. The mastitis usually caused by a bacterial infection is the most prevalent disease and the greatest source of lost revenue, about hundreds milloin dollar annually in Japan. In my previous work, mice milk contains L-amino acid oxidase (LAO), a enzyme decomposes particular free amino acid and generates hydrogen peroxide. LAO-knockout mice exhibited weak resistance to an intramammary bacterial infection. In dairy cattle, the expression level of LAO seems quite small compared to mice. I believe if we can enhance the LAO expression endogenously, it will enable the generation of mastitis resistance cow.

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About TUAT's tenure-track program

This program is nice for young scientists. To keep it on TUAT and Japan, We will also need to be nice scientist. I hope this program would be more improved consistently for next generation.

Future aspirations

I would like to always keep double standard in my mind; one is going the basic research for battle with other researchers and survive in the scientific world, another is doing applied research based on practical science to resolve facing problems in veterinary, animal science and other fields. I know it is hard task, but I would do and finally make an attractive laboratory.