Kawano Ryuji:Tenured Faculties|TUAT's tenure-track program

Research Support Office Research Advancement Division. Tokyo University of Agriculture and Technology

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Kawano Ryuji

Affiliation	Institute of Engineering
Division	Division of Biotechnology and Life Science
Research field	Single Molecule Detection, BioMEMS
Keyword(S)	Lipid bilayer, Membrane proteins, Microfluidics, Nanopore
Url	http://web.tuat.ac.jp/~rjkawano/

Research experience	･2005: Lecturer, VBL, Yokohama National Univsersity ･2006: JSPS Postdoctroal Fellow, University of Utah ･2008: Postdoctral Fellow, University of Utah ･2009: Researcher, Kanagawa Academy of Science and Technology ･Jan.2014 - Dec.2018: Associate Professor, Tokyo University of Agriculture and Technology ･Jan.2019 - Sep.2020: Associate Professor(Tenured), Tokyo University of Agriculture and Technology ･Oct.2020 - Present: Professor, Tokyo University of Agriculture and Technology
Educational background	･2000: B. Eng., Tokyo Metropolitan University ･2005: Ph. D., Yokohama National University
Awards	* The latest information is shown at the member's website. (At Jan. 2019) ･2003: The 83th Annual Meeting of The Chemical Society of Japan, Student Presentation Award ･2006: The 88th Annual Meeting of The Chemical Society of Japan, Presentation Award ･2018: Tokyo University of Agriculture and Technology, President's Award
Selected papers and publications	* The latest information is shown at the member's website. (At Jan. 2019) ・R. Kawano " Nanopore Decoding of Oligonucleotides in DNA Computing " Biotech. J. (Invited Review) 2018 in press. ・R. Kawano " Synthetic Ion Channels and DNA Logic Gates as Components of Molecular Robots " ChemPhysChem (Invited Minireview) 2018 19, 369. ・M. Hiratani et al. "DNA Logic Operation with Nanopore Decoding To Recognize MicroRNA Patterns in Small Cell Lung Cancer" Anal. Chem. 2018 90, 8531. ・R. Kawano et al. "Metal-Organic Cuboctahedra for Synthetic Ion Channels with Multiple Conductance States" Chem 2017 2, 393. ・M Ohara et al. "Nanopore Logic Operation with DNA to RNA Transcription in a Droplet System" ACS Synth. Biol. 2017 6, 1427. ・K. Kamiya et al. "Cell-sized asymmetric lipid vesicles facilitate the investigation of asymmetric membranes" Nature Chem. 2016 8, 881.

Research Description

The goal of my research is to establish a system that uses biological nanopores for single-molecule detection. Channel membrane proteins have nanochannels around 1 nm in size. These biological nanopores are capable of detecting and electrically recognize even single molecules with a high signal-to-noise ratio. However, the channel size is limited by the inherent protein structure. I plan to develop artificial nanochannels such as synthetic nanopores or polypeptides combined with biomaterials (proteins and lipid bilayers) on the basis of MEMS technology for novel nanopore sensing.

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About TUAT's tenure-track program

The tenure track program in TAT provides the provision of space and start-up funds for independent research and work for tenure track faculty. This program is promising that young researchers dedicate themselves completely to their research and education.

Future aspirations

I combine themes at the forefront of nanoscience, biomolecular engineering, and electrochemistry, for the development of innovative analytical tools and their application in both the physical and life sciences. Examples include the development of sensitive, nanometer scale chemical and biological sensors that will probe materials and biological systems with unprecedented temporal and spatial resolution. Member in my lab will gain a highly interdisciplinary background electrochemistry, biochemistry, nanotechnology and biomolecular engineering pushing the frontiers of basic science while also narrowing the gap between laboratory-bound research and real-world applicability.