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Home > Tenured Faculties > Nakazawa Yasumoto

Tenured Faculties

Nakazawa Yasumoto

Affiliation Institute of Engineering
Division Division of Biotechnology and Life Science
Research field Biomaterial, Tissue Engineering
Keyword(S) Silk, NMR, Artificial vascular graft
Url
Research experience

・Apr.2003 - Mar.2004 : Project Researcher, Tokyo University of Agriculture and Technology
・Apr.2004 - Mar.2007 : JSPS Research Fellow
・Jun.2007 - Jan.2013 : Assistant Professor, Tokyo University of Agriculture and Technology
・Feb.2013 - Jan.2018 : Associate Professor, Tokyo University of Agriculture and Technology
・Feb.2018 - Sep.2020 : Associate Professor(Tenured), Tokyo University of Agriculture and Technology
・Oct.2020 - Present : Professor, Tokyo University of Agriculture and Technology

Educational background

・1998 B. Sc., Department of Chemistry, Tokyo University of Science
・2000 M. E., Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
・2003 Ph. D., Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology

Awards

* The latest information is shown at the member's website.
(At Feb. 2013)
・2002 Young Scientists Poster Awards; The NMR Society of Japan
・2009 Award for Encouragement of Reseach in Polymer Science: The Sciety of Polymer Science, Japan

Selected papers and publications

* The latest information is shown at the member's website.
(At Feb. 2013)
・Nakazawa, Y., Asakura, T., "High Resolution 13C CP/MAS NMR Study on Structure and Structural Transition of Antheraea pernyi Silk Fibroin containing Poly(L-alanine) and Gly rich Regions. ", Macromolecules 35, p.2393-2400 (2002)
・Nakazawa, Y., Asakura, T., "Structure determination of a peptide model of the repeated helical domain in Samia cynthia ricini silk fibroin before spinning by a combination of advanced solid-state NMR methods.", J. Am. Chem. Soc. 125, p.7230-7237 (2003)
・Asakura, T., Nakazawa, Y., Ohnishi, E., Moro, F., "Evidence from 13C solid-state NMR spectroscopy for a lamella structure in an alanine-glycine copolypeptide: a model for the crystalline domain of Bombyx mori silk fiber.", Protein Sci., 14, p.2654-2657(2005)
・Tetsuo Asakura, Yasumoto Nakazawa, "Structural Analysis of Silk Fibroins using NMR", Modern Magnetic Resonance Vol.1. Application in Chemistry (Edited by Graham A. Webb), Springer, pp.97-102 (2007)
・Nakazawa, Y., Suzuki, Y., Williamson, M. P., Saito, H., Asakura, T., "The interaction of amyloid Aβ(1-40) with lipid bilayers and ganglioside as studied by 31P solid-state NMR.", Chem. Phys. Lipids 158, p.54-60(2009)
・Yasumoto Nakazawa, Yu Suzuki, Hazime Saitô, and Tetsuo Asakura, "The Interaction of Aβ(1-40) Peptide with Lipid Bilayers and Ganglioside As Studied by Multinuclear Solid-State NMR", NMR Spectroscopy of Polymers: Innovative NMR Strategies for Complex Macromolecular Systems, ACS Symposium Series Vol.1077, Chapter 18, American Chemical Society, pp.299-316 (2011)
・Nakazawa, Y., Sato, M., Takahashi, R., Yamazaki, S., Takabayashi, C., Tamura, T., Enomoto, S., Sata, M., Asakura, T., "Development of Small-Diameter Vascular Grafts based on Silk Fibroin Fibers from B. mori for Vascular Regeneration.", J. Biomater. Sci. Polym. Ed. 22, p.195-206 (2011)
・Nakazawa, Y., Asano, A., Nakazawa, C., Tsukatani, T., Asakura, T., "Structural characterization of the silk-polyurethane composite material for the biomaterials using solid-state NMR", Polymer Journal, 44, p.802-807 (2012)

Research Description

I have studied about the structure of natural fibers particularly about silk fibroins by using solid state NMR method. Based on the research achievements, I am trying to develop the artificial vessels with small diameter made of silks.

Silk fibroin from Bombyx mori silkworm has outstanding mechanical properties despite being spun from aqueous solution. Now, I have clarified two distinct structures in the solid state, silk I and silk II which mean the structures before and after spinning, by using solid state NMR. Moreover I have been developing several kinds of biomaterials, such as bone regeneration materials and vascular grafts. In the case of vascular regeneration, we have developed the small diameter vascular grafts made by silk fibroins. As results, the new grafts from silk fibroins have good patency, and these grafts were commonly covered with cells and platelets at 4 weeks after implantation.

Now I will try to develop other regenerative medical devices such as an artificial cardiac valve and wound dressing from silk fibroins on the basis of following techniques.

The PDF file can be downloaded from URL

About TUAT's tenure-track program

One of the attractive points of this tenure-track program is that I can work on my own research independently. I appreciate to be given the opportunity to research under enough fund and support from a mentor.
My research career on this position is quite primitive. I will concentrate on my own research and educational activity for my students and achieve my best performance.
The growing availability of this program is good for young researchers to imagine their future work.

Future aspirations

I will study about out of my past research field like biology, material engineering, medicine, polymers and so on, and combine the knowledge and the technologies with my past results. I hope to break ground in the field of tissue engineering and regenerative medicine and contribute to the medical field.
I also want to give the findings back to academic educational activity. I hope for my student to have a good experience such as moving by getting new knowledge or successful in their research.