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Home > Tenured Faculties > Saito Akio

Tenured Faculties

Saito Akio

Affiliation Institute of Engineering
Division Division of Applied Chemistry
Research field Organic Synthetic Chemistry
Keyword(S) Heterocyclic synthesis, Iodine, Domino reaction
Url http://web.tuat.ac.jp/~akio-sai/
Research experience

Apr. 2001-Mar. 2005 : Research Associate, Tokyo University of Pharmacy and Life Sciences
Apr. 2005-Mar. 2007 : Research Associate, Showa Pharmaceutical University
Apr. 2007-Mar. 2008 : Assistant Professor, Showa Pharmaceutical University
Apr. 2008-Apr. 2012 : Senior Assistant Professor, Showa Pharmaceutical University
May. 2012-Apr. 2017 : Associate Professor, Tokyo University of Agriculture and Technology
May. 2017-Present : Associate Professor(Tenured), Tokyo University of Agriculture and Technology

Educational background

1997 B. Sc. Tokyo University of Pharmacy and Life Sciences
1999 M. Sc. Tokyo University of Pharmacy and Life Sciences
2003 Ph. D. Tokyo University of Pharmacy and Life Sciences

Awards

* The latest information is shown at the member's website.
(At May. 2012)
2008 The Pharmaceutical Society of Japan Kanto Branch Award for Young Scientists
2008 Poster Award in OMCOS-14 (The 14th International Symposium on Organometallic Chemistry Directed towards Organic Synthesis)

Selected papers and publications

* The latest information is shown at the member's website.
(At May. 2012)
A. Saito, A. Kanno, Y. Hanzawa, "Synthesis of 2,3-Disubstituted Indoles by a Rhodium-Catalyzed Aromatic Amino-Claisen Rearrangement of N-Propargyl Anilines", Angew. Chem. Int. Ed. 2007, 46, 3931-3933.

A. Saito, M. Umakoshi, N. Yagyu, Y. Hanzawa, "Novel One-Pot Approach to Synthesis of Indanones through Sb(V)-Catalyzed Reaction of Phenylalkynes with Aldehydes", Org. Lett. 2008, 10, 1783-1785.

A. Saito, T. Konishi, Y. Hanzawa, "Synthesis of Pyrroles by Gold(I)-Catalyzed Amino−Claisen Rearrangement of N-Propargyl Enaminone Derivatives", Org. Lett. 2010, 12, 372-374.

A. Saito, T. Anzai, A. Matsumoto, Y. Hanzawa, "PIFA-Mediated Oxidative Cycloisomerization of 2-Propargyl-1,3-Dicarbonyl Compounds: Divergent Synthesis of Furfuryl Alcohols and Furfurals", Tetrahedron Lett. 2011, 52, 4658-4661.

Research Description

"Heterocyclic nuclei have been found in the wide variety of chemicals such as pharmaceutical agents, agrochemicals, and functional materials. The most of commonly used procedures of heterocyclic syntheses, however, require 1) harsh reaction conditions, 2) multiple reaction processes, and 3) stoichiometric amounts of activated reagents. From the viewpoint of environmentally benign organic synthesis, it is critical to develop novel and efficient procedures of heterocyclic synthesis. On the other hand, transition metal-catalyzed formations of carbon-carbon and carbon-hetero atom bonds proceed with atom economy under the mild conditions. Recently, various metal catalysts have been found to activate consecutive bond formations in a single step. Such consecutive metal-catalyzed processes provide not only short-step syntheses with no involvement of workup and isolation of many intermediates but clean and atom economical procedures. Thus, toward novel and efficient procedures of heterocyclic synthesis, we undertake the research on the consecutive catalytic processes. Our recent works are as follows:
a) Rh(I) or Au(I)-catalyzed domino synthesis of heterocyclic compounds based on Claisen rearrangement
b) Lewis acid or Brønsted-catalyzed domino synthesis of heterocyclic compounds based on hetero-enyne metathesis
c) Metal-free oxidative cyclization for the synthesis of heterocyclic compounds concomitantly with the incorporation of oxygen functional groups into side chains"

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About TUAT's tenure-track program

We, the tenure-track faculty members, are allowed to receive the high budget with less administrative duties for a certain period so that we can start up our own researches in our independent laboratories. Although we will undergo tenure reviews twice, we do not have to get a limited number of tenure appointments competitively. Our post-approval positions are provided under this program, and thus we are able to win tenure depending on our efforts. Such a great program encourages us to carry out our research activities.

Future aspirations

Since organic synthesis reactions based on consecutive catalytic processes have been attracted, such reactions are critical to be applied to the heterocyclic syntheses for the efficient supplies of valuable chemicals. Thus, the present researches would be promoted to lead interesting results and great outcomes. As one of faculty members, I would do my best job of education to produce people who are active in the modern society.